Seminario "Biological age and the microbiome"
Sala Manuel de Terán 3F
En el marco del Ciclo de Seminarios del proyecto ERC-Advanced ECHO
Por Hiram Beltrán-Sánchez (UCLA)
Organiza: Proyecto ECHO-ERC (IEGD-CSIC)
In this presentation we propose the formulation of an alternative biological clock (BA) that takes into account indicators from the microbiome (richness, evenness, and deviant taxa) as additional set of indicators for a domain not yet included in extant clocks. We will use data from the Survey of the Health of Wisconsin (SHOW) that has been collected annually since 2008 and it is representative of residents in the State of Wisconsin in the US. We use a structural equation model (SEM) to fully formalize the relations between a latent trait, BA, and observables such as chronological age (CA), biomarkers, epigenetic domains assessed by multiple epigenetic clocks, and the microbiome.
